Immune molecule links COVID‑19 with severe inflammatory disorder in children

The immune molecule TGFβ has been found to weaken immune defences against latent viruses, triggering reactivation of the Epstein–Barr virus. This mechanism links TGFβ release in SARS-CoV-2 infection to multisystem inflammatory syndrome in children, and could inform the development of therapies for managing this serious condition. The molecule TGFβ suppresses the ability of T cells to protect against latent Epstein–Barr virus.

Publication Details

Journal
Nature
Published
2025-03-12
DOI
https://doi.org/10.1038/d41586-025-00735-7
Primary Topic
Kawasaki Disease and Coronary Complications
Type
article
Field-Weighted Citation Impact
0.00
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article

Immune molecule links COVID‑19 with severe inflammatory disorder in children

Nature
Kawasaki Disease and Coronary Complications
article

Immune molecule links COVID‑19 with severe inflammatory disorder in children

article en

Abstract

The immune molecule TGFβ has been found to weaken immune defences against latent viruses, triggering reactivation of the Epstein–Barr virus. This mechanism links TGFβ release in SARS-CoV-2 infection to multisystem inflammatory syndrome in children, and could inform the development of therapies for managing this serious condition. The molecule TGFβ suppresses the ability of T cells to protect against latent Epstein–Barr virus.

Nature
Openalex Percentile: Top 92%
Kawasaki Disease and Coronary Complications
DOIOpen Access PDFOpenAlex
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Immune molecule links COVID‑19 with severe inflammatory disorder in children · Nature (2025) | TGRS Research Map | TGRS