Multinuclear Silver(I)–Selenium Clusters Formation in Selenopeptides

The reactions of ionic silver (Ag<sup>+</sup>) with arginine vasopressin (AVP), a nonapeptide hormone cyclized by two cysteine residues, and its diselenium analogue was explored by an integrated LC-MS, UV-vis, and DFT approach. The replacement of Cys by SeCys in AVP increased the reactivity of the peptide toward Ag<sup>+</sup> ions under mildly reducing conditions, with the formation of a Se<sub>4</sub>Ag<sub>4</sub> cluster provided by Ag(I)-mediated dimerization of diselenide AVP. Specific electronic absorption bands confirmed the formation of the Ag<sub>4</sub>peptide<sub>2</sub> complex, supported by DFT calculations. These results provide the first ever evidence that Ag(I) ions bind a selenopeptide and prefer SeCys over Cys as binding sites, opening a perspective on the involvement of selenobiomolecules in the emerging cellular toxicity of silver.

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Publication Details

Journal
Inorganic Chemistry
Published
2025-03-12
DOI
https://doi.org/10.1021/acs.inorgchem.4c04867
Primary Topic
Nanocluster Synthesis and Applications
Type
article
Field-Weighted Citation Impact
0.00

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article

Multinuclear Silver(I)–Selenium Clusters Formation in Selenopeptides

Joanna Szpunar, Wojciech Bal, Luisa Ronga, Paulina Szczerba et al.
Inorganic Chemistry
Nanocluster Synthesis and Applications
article

Multinuclear Silver(I)–Selenium Clusters Formation in Selenopeptides

Joanna Szpunar, Wojciech Bal, Luisa Ronga, Paulina Szczerba, Karinne Miqueu, Ioannis Kanavos, Alejandro Gutiérrez‐Quintanilla, Panaghiotis Karamanis, Tshering Zangmo
article en

Abstract

The reactions of ionic silver (Ag<sup>+</sup>) with arginine vasopressin (AVP), a nonapeptide hormone cyclized by two cysteine residues, and its diselenium analogue was explored by an integrated LC-MS, UV-vis, and DFT approach. The replacement of Cys by SeCys in AVP increased the reactivity of the peptide toward Ag<sup>+</sup> ions under mildly reducing conditions, with the formation of a Se<sub>4</sub>Ag<sub>4</sub> cluster provided by Ag(I)-mediated dimerization of diselenide AVP. Specific electronic absorption bands confirmed the formation of the Ag<sub>4</sub>peptide<sub>2</sub> complex, supported by DFT calculations. These results provide the first ever evidence that Ag(I) ions bind a selenopeptide and prefer SeCys over Cys as binding sites, opening a perspective on the involvement of selenobiomolecules in the emerging cellular toxicity of silver.

Inorganic ChemistryVol. 64(11)
Centre National de la Recherche Scientifique (FR), Université de Pau et des Pays de l'Adour (FR), Institut des Sciences Analytiques et de Physico-Chimie pour l'Environnement et les Matériaux (FR), Institute of Biochemistry and Biophysics, Polish Academy of Sciences (PL)
Narodowe Centrum Nauki, Conseil Régional Aquitaine, Université de Pau et des Pays de l'Adour, H2020 Marie Skłodowska-Curie Actions
Openalex Percentile: Top 97%
Nanocluster Synthesis and Applications
DOIOpen Access PDFOpenAlex
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Multinuclear Silver(I)–Selenium Clusters Formation in Selenopeptides — Joanna Szpunar, Wojciech Bal, et al. · Inorganic Chemistry (2025) | TGRS Research Map | TGRS