Short-Term Safety and Effectiveness for Tenecteplase and Alteplase in Acute Ischemic Stroke

This large, nationwide comparative effectiveness study using data from routine clinical practice demonstrated similar effectiveness and safety outcomes with tenecteplase compared with alteplase in patients with acute ischemic stroke. This study supports tenecteplase as a reasonable alternative to alteplase.

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Institutions

Publication Details

Journal
JAMA Network Open
Published
2025-03-12
DOI
https://doi.org/10.1001/jamanetworkopen.2025.0548
Citations
9
Primary Topic
Acute Ischemic Stroke Management
Type
article
Field-Weighted Citation Impact
12.19
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article

Short-Term Safety and Effectiveness for Tenecteplase and Alteplase in Acute Ischemic Stroke

Jeremy M. Weber, Steven R. Messé, Brooke Alhanti, Eric Edward Smith et al.
9 citations
JAMA Network Open
Acute Ischemic Stroke Management
12.19
article

Short-Term Safety and Effectiveness for Tenecteplase and Alteplase in Acute Ischemic Stroke

Jeremy M. Weber, Steven R. Messé, Brooke Alhanti, Eric Edward Smith, Ying Xian, Justin F. Rousseau, Gisele Sampaio Silva, Michael T. Mullen, Brian Mac Grory, Kevin Navin Sheth, Steven Warach, Gregg C. Fonarow, Jeffrey L. Saver, Lee H. Schwamm
article en
9 citations

Abstract

This large, nationwide comparative effectiveness study using data from routine clinical practice demonstrated similar effectiveness and safety outcomes with tenecteplase compared with alteplase in patients with acute ischemic stroke. This study supports tenecteplase as a reasonable alternative to alteplase.

JAMA Network OpenVol. 8(3)
Ascension (US), University of California, Los Angeles (US), University of Calgary (CA), Duke University (US), Hospital of the University of Pennsylvania (US), Hospital Israelita Albert Einstein (BR), Ronald Reagan UCLA Medical Center (US), Yale University (US), Clinical Research Institute (US), Temple University (US), The University of Texas at Austin (US), The University of Texas Southwestern Medical Center (US), Universidade Federal de São Paulo (BR)
Good health and well-being
Openalex Percentile: Top 1%
Acute Ischemic Stroke Management
12.19
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