Short-Term Safety and Effectiveness for Tenecteplase and Alteplase in Acute Ischemic Stroke
This large, nationwide comparative effectiveness study using data from routine clinical practice demonstrated similar effectiveness and safety outcomes with tenecteplase compared with alteplase in patients with acute ischemic stroke. This study supports tenecteplase as a reasonable alternative to alteplase.
Authors
- Jeremy M. Weber (ORCID: https://orcid.org/0000-0002-7221-8821)
- Steven R. Messé (ORCID: https://orcid.org/0000-0003-3108-5441)
- Brooke Alhanti (ORCID: https://orcid.org/0000-0003-4243-8062)
- Eric Edward Smith (ORCID: https://orcid.org/0000-0003-3956-1668)
- Ying Xian (ORCID: https://orcid.org/0000-0002-1237-1162)
- Justin F. Rousseau (ORCID: https://orcid.org/0000-0002-2817-9124)
- Gisele Sampaio Silva (ORCID: https://orcid.org/0000-0002-3247-3123)
- Michael T. Mullen (ORCID: https://orcid.org/0000-0001-8300-7731)
- Brian Mac Grory (ORCID: https://orcid.org/0000-0003-3914-8419)
- Kevin Navin Sheth (ORCID: https://orcid.org/0000-0003-2003-5473)
- Steven Warach (ORCID: https://orcid.org/0000-0003-3125-7979)
- Gregg C. Fonarow (ORCID: https://orcid.org/0000-0002-3192-8093)
- Jeffrey L. Saver (ORCID: https://orcid.org/0000-0001-9141-2251)
- Lee H. Schwamm (ORCID: https://orcid.org/0000-0003-0592-9145)
Institutions
- Ascension (US)
- University of California, Los Angeles (US)
- University of Calgary (CA)
- Duke University (US)
- Hospital of the University of Pennsylvania (US)
- Hospital Israelita Albert Einstein (BR)
- Ronald Reagan UCLA Medical Center (US)
- Yale University (US)
- Clinical Research Institute (US)
- Temple University (US)
- The University of Texas at Austin (US)
- The University of Texas Southwestern Medical Center (US)
- Universidade Federal de São Paulo (BR)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-03-12
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.0548
- Citations
- 9
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 12.19