Evaluation of antiseizure medication concentration ranges in blood samples using an automated big data approach
The applied automated approach can facilitate a fast and efficient method for comparing established reference ranges with nationwide TDM datasets, thereby allowing continual monitoring of laboratory reference ranges. The findings from this study suggest that the Danish reference range for levetiracetam should be reevaluated. Furthermore, dose adjustment may be relevant for levetiracetam, topiramate, and lacosamide to account for age-related changes in metabolism. The lower concentration range for lamotrigine in the psychiatric population indicates that it may be effective at lower concentrations in patients with bipolar disorder compared to patients with epilepsy.
Authors
- Andreas Brønden (ORCID: https://orcid.org/0000-0003-1262-3769)
- Eva Greibe (ORCID: https://orcid.org/0000-0002-0417-1195)
- Lasse K. Bak (ORCID: https://orcid.org/0000-0003-0784-7864)
- Jakob Christensen (ORCID: https://orcid.org/0000-0002-9385-6435)
- Palle Bach Nielsen Fruekilde (ORCID: https://orcid.org/0000-0002-7274-8486)
- Mariam Nersesjan (ORCID: https://orcid.org/0000-0002-9975-6216)
- Lars Engers Pedersen
- Per Hersom Aaslo
- Elke Hoffmann (ORCID: https://orcid.org/0000-0002-2437-0140)
- Jens Borggaard Larsen (ORCID: https://orcid.org/0009-0008-3462-5849)
- Anette Kirstine Stark
Institutions
- University of Copenhagen (DK)
- Aarhus University (DK)
- Frederiksberg Hospital (DK)
- Odense University Hospital (DK)
- Aarhus University Hospital (DK)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
- Slagelse Hospital (DK)
- Holbæk Sygehus (DK)
- Filadelfia (DK)
Publication Details
- Journal
- Epilepsia
- Published
- 2025-03-12
- DOI
- https://doi.org/10.1111/epi.18330
- Citations
- 1
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.47