<i>EWSR1::CREM</i> Fusion in a Pediatric Patient With Testicular Leydig Cell Tumor
Sex cord-stromal tumors are rare in pediatric patients. Leydig cell tumors are a rare subset of sex cord-stromal tumors characterized by unique molecular alterations, including TERT fusions and mutations of CTNNB1, FOXO4, TP53, NBN, MTOR, BAP1, MEN1, and CREBBP. We report a case of a testicular Leydig cell tumor with an EWSR1::CREM fusion, which to our knowledge has not been previously reported in this setting.
Authors
- Patrick R. Blackburn (ORCID: https://orcid.org/0000-0003-0658-1275)
- Alberto S. Pappo (ORCID: https://orcid.org/0000-0002-5338-3979)
- Megan M. Lilley (ORCID: https://orcid.org/0000-0002-1145-314X)
- Selene C. Koo (ORCID: https://orcid.org/0000-0001-8459-2469)
- Larissa V. Furtado (ORCID: https://orcid.org/0000-0001-7784-9502)
Institutions
- St. Jude Children's Research Hospital (US)
Publication Details
- Journal
- Genes Chromosomes and Cancer
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/gcc.70038
- Citations
- 1
- Primary Topic
- Testicular diseases and treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- American Lebanese Syrian Associated Charities