Evaluation of omadacycline <i>in vitro</i> activity against <i>Corynebacterium</i> species
<i>Corynebacterium</i> spp. are gram-positive bacteria increasingly recognized as pathogens. This study evaluates the MICs of omadacycline, a tetracycline, against 40 clinical <i>Corynebacterium</i> isolates using two methodologies: broth microdilution (BMD) and Liofilchem omadacycline MIC Test Strip (MTS). By BMD, the MIC<sub>50</sub>, MIC<sub>90</sub>, and MIC range were 0.5 µg/mL, 1 µg/mL, and 0.12-2.0 µg/mL, respectively. Comparing BMD to MTS, essential agreement (EA, within ±1 doubling dilution of the reference BMD MIC) was 87.5% (95% CI: 73.0%-95.4%).
Authors
- Justin McCallum
- Saltanat Ualiyeva (ORCID: https://orcid.org/0000-0002-2899-1366)
- Alexander Pyden (ORCID: https://orcid.org/0000-0003-0602-0056)
- Zoe Weiss (ORCID: https://orcid.org/0000-0003-2931-3660)
Institutions
- Tufts Medical Center (US)
- Lahey Medical Center (US)
Publication Details
- Journal
- Antimicrobial Agents and Chemotherapy
- Published
- 2025-03-12
- DOI
- https://doi.org/10.1128/aac.01864-24
- Citations
- 1
- Primary Topic
- Diphtheria, Corynebacterium, and Tetanus
- Type
- article
- Field-Weighted Citation Impact
- 1.80