SENP1-SIRT3 axis mediates glycolytic reprogramming to suppress inflammation during <i>Listeria monocytogenes</i> infection
Sentrin-specific protease 1 (SENP1)-sirtuin 3 (SIRT3) has never been reported in the regulation of bacteria-induced inflammation. Our study demonstrated that SENP1 acted as a protective factor against <i>Listeria</i>-induced inflammation by promoting SIRT3 activation and subsequent metabolic reprogramming. The SENP1-SIRT3 axis served not only as an essential signaling pathway for regulating mitochondrial metabolic responses to metabolic stress but also responds to bacterial invasion and plays a protective role in the organism. Our findings provide a basis for further research into targeting the SENP1-SIRT3 signaling pathway for the treatment of bacterial infections.
Authors
- Haibo Wu (ORCID: https://orcid.org/0000-0002-5961-2947)
- Dong Guo (ORCID: https://orcid.org/0000-0001-9877-4036)
- Rong Tian (ORCID: https://orcid.org/0000-0002-3676-3830)
- Zhou Sha
- Xiaoyuan Lin (ORCID: https://orcid.org/0000-0002-3361-0126)
- Bohao Li (ORCID: https://orcid.org/0000-0003-2518-921X)
- Lulu Wang (ORCID: https://orcid.org/0000-0001-7466-9522)
- Yan Xiong (ORCID: https://orcid.org/0000-0001-5507-6991)
- Yongliang Du
- Rui Yao (ORCID: https://orcid.org/0000-0003-4858-3551)
- Lin Feng (ORCID: https://orcid.org/0000-0002-4255-8171)
- Beibei Fu
- Z Cong
Institutions
- Army Medical University (CN)
- Chongqing University (CN)
- Hygeia Hospital (GR)
Publication Details
- Journal
- mBio
- Published
- 2025-03-12
- DOI
- https://doi.org/10.1128/mbio.02524-24
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China