Differentiation of anterior chamber pigment and inflammatory cells using swept-source optical coherence tomography: a cross-sectional study
Swept-source (SS) AS-OCT holds potential utility in differentiating between pigment and cells within the AC, leading to improved management of individuals with or at risk of intraocular inflammation. SS AS-OCT-derived biomarkers may also provide information on uveitis aetiology, supporting the diagnosis of underlying conditions. Further work on a larger cohort, replication by other investigators and clinical teams, and clinical correlation with anterior chamber sampling will enable future clinical validation.
Authors
- Ameenat Lola Solebo (ORCID: https://orcid.org/0000-0002-8933-5864)
- Harry Petrushkin (ORCID: https://orcid.org/0000-0002-4662-2994)
- Alice Bellchambers (ORCID: https://orcid.org/0000-0003-3509-6906)
- Colin J. Chu (ORCID: https://orcid.org/0000-0003-2088-8310)
- Rongling Shu
Institutions
- Great Ormond Street Hospital (GB)
- Great Ormond Street Hospital for Children NHS Foundation Trust (GB)
- University College of Osteopathy (GB)
- National Institute for Health and Care Research (GB)
- NIHR Moorfields Biomedical Research Centre (GB)
- East Sussex Healthcare NHS Trust (GB)
- Moorfields Eye Hospital (GB)
- University College London (GB)
Publication Details
- Journal
- Eye
- Published
- 2025-03-12
- DOI
- https://doi.org/10.1038/s41433-025-03697-2
- Citations
- 5
- Primary Topic
- Ocular Diseases and Behçet’s Syndrome
- Type
- article
- Field-Weighted Citation Impact
- 8.54
Funders
- National Institute for Health and Care Research