Exploring shared therapeutic targets for Alzheimer’s disease and glioblastoma using network pharmacology and protein-protein interaction approach
The present study provides a strong computational foundation for further <i>in vitro</i> and <i>in vivo</i> validation. The results highlight the potential of luteolin in developing dual-target treatment strategies for neurodegenerative and oncological disorders, offering new avenues for therapeutic advancements.
Authors
- E. S. Sushmitha
- Natalia Manturova (ORCID: https://orcid.org/0000-0001-6935-709X)
- Ekaterina Silina (ORCID: https://orcid.org/0000-0002-0246-5149)
- Sushma Pradeep (ORCID: https://orcid.org/0000-0002-9403-234X)
- Divya Suresh
- Madhusudan Purohit (ORCID: https://orcid.org/0000-0002-4356-3423)
- Chandan Shivamallu (ORCID: https://orcid.org/0000-0002-1886-139X)
- Victor Stupin (ORCID: https://orcid.org/0000-0002-9522-8061)
- Shiva Prasad Kollur (ORCID: https://orcid.org/0000-0003-3914-3933)
- Raghu Ram Achar (ORCID: https://orcid.org/0000-0001-8196-3703)
- S. Nanjunda Swamy (ORCID: https://orcid.org/0000-0002-5494-9428)
- Pruthvish Reddy
- M. R. Sai Chakith
- S. R. Sindhushree
Institutions
- JSS Academy of Higher Education and Research (IN)
- Sechenov University (RU)
- Pirogov Russian National Research Medical University (RU)
- JSS Science and Technology University (IN)
- Amrita Vishwa Vidyapeetham (IN)
Publication Details
- Journal
- Frontiers in Chemistry
- Published
- 2025-03-12
- DOI
- https://doi.org/10.3389/fchem.2025.1549186
- Citations
- 16
- Primary Topic
- Computational Drug Discovery Methods
- Type
- article
- Field-Weighted Citation Impact
- 24.07