Inhibition of CD53 Reduces the Formation of ROS-Induced Neutrophil Extracellular Traps and Protects Against Inflammatory Injury in Acute Pancreatitis
The results of this study mark the first confirmation that CD53 plays a crucial role in NETs formation. Targeting CD53 inhibition could potentially serve as a novel therapeutic approach for the treatment of AP.
Authors
- Weijuan Gong (ORCID: https://orcid.org/0000-0002-8543-1314)
- Guotao Lu (ORCID: https://orcid.org/0000-0002-8325-0405)
- Yaodong Wang
- Weiming Xiao (ORCID: https://orcid.org/0000-0002-8893-9076)
- Xiaochun Xie (ORCID: https://orcid.org/0000-0001-6826-9493)
- Chenchen Yuan (ORCID: https://orcid.org/0000-0002-0551-0718)
- Yaning Wang (ORCID: https://orcid.org/0000-0002-2503-2821)
- Fei Han (ORCID: https://orcid.org/0000-0003-3914-1073)
- Tianqi Xia (ORCID: https://orcid.org/0000-0002-2078-2279)
- Bo Tu (ORCID: https://orcid.org/0000-0002-7526-2588)
- Hongbo Ren (ORCID: https://orcid.org/0000-0002-7667-535X)
Institutions
- Fred Hutch Cancer Center (US)
- Shanghai University of Traditional Chinese Medicine (CN)
- Traditional Chinese Medicine Hospital of Kunshan (CN)
- Qilu Hospital of Shandong University (CN)
- Yangzhou University (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-03-01
- DOI
- https://doi.org/10.2147/jir.s507886
- Citations
- 1
- Primary Topic
- Pancreatitis Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.01