Vestibular modulation by stimulant derivatives in a pentameric ligand‐gated ion channel
This work provides a detailed structure-function mechanism for allosteric potentiation via a noncanonical ligand site, with potential conservation of the eukaryotic pentameric ligand-gated ion channels.
Authors
- Erik Lindahl (ORCID: https://orcid.org/0000-0002-2734-2794)
- Rebecca J. Howard (ORCID: https://orcid.org/0000-0003-2049-3378)
- Marc Delarue (ORCID: https://orcid.org/0000-0003-0723-8102)
- Zaineb Fourati (ORCID: https://orcid.org/0000-0002-2316-4142)
- Yuxuan Zhuang (ORCID: https://orcid.org/0000-0003-4390-8556)
- Emelia Karlsson
- Chen Fan (ORCID: https://orcid.org/0000-0003-1211-3427)
- Ahmed Haouz (ORCID: https://orcid.org/0000-0003-1196-1635)
- Olivia Andén (ORCID: https://orcid.org/0009-0002-4816-5691)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Institut Pasteur (FR)
- Stockholm University (SE)
- Université Paris Cité (FR)
- Science for Life Laboratory (SE)
- Laboratoire de Cristallographie et RMN Biologiques (FR)
- KTH Royal Institute of Technology (SE)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1111/bph.70011
- Citations
- 1
- Primary Topic
- Nicotinic Acetylcholine Receptors Study
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Eli Lilly and Company
- Kempe Foundation
- Swedish e-Science Research Centre
- Vetenskapsrådet
- Kempestiftelserna
- Stockholms Universitet
- Science for Life Laboratory