The Impact of Once Daily Dosing on Protein Binding of Clozapine and Norclozapine
In general, total concentrations remain suitable for therapeutic drug monitoring if clozapine is used once daily. Future research is needed to define if higher total concentrations are warranted in case of lower unbound fractions due to increased AGP concentrations.
Authors
- Marieke M. Beex‐Oosterhuis (ORCID: https://orcid.org/0000-0002-3070-3626)
- Gunnar Faber
- Daan J. Touw (ORCID: https://orcid.org/0000-0002-1429-4789)
- Rob J. van Marum (ORCID: https://orcid.org/0000-0003-4292-532X)
- Koen P. Grootens (ORCID: https://orcid.org/0000-0001-7458-107X)
- Eibert Roelof Heerdink (ORCID: https://orcid.org/0000-0002-5946-7209)
- Charlotte van Kesteren (ORCID: https://orcid.org/0000-0001-9071-6421)
- Cedric Lau (ORCID: https://orcid.org/0000-0001-5062-9331)
- Arthur R. Van Gool (ORCID: https://orcid.org/0000-0003-3220-1061)
- Steven Verloop
Institutions
- Albert Schweitzer Hospital (GA)
- University of Applied Sciences Utrecht (NL)
- Tilburg University (NL)
- University Medical Center Utrecht (NL)
- Albert Schweitzer Ziekenhuis (NL)
- Amsterdam Neuroscience (NL)
- Pharmo Institute (NL)
- Amsterdam Public Health (NL)
- Yulius (NL)
- Reinier van Arkel (NL)
Publication Details
- Journal
- Journal of Clinical Psychopharmacology
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1097/jcp.0000000000001979
- Primary Topic
- Schizophrenia research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00