The Effect of COVID-19 Vaccination on the Risk of Persistent Post–COVID-19 Condition: Cohort Study

We conducted a population-based cohort study in Stockholm, Sweden, to investigate the effect of COVID-19 vaccination on the risk of developing persistent post-COVID-19 condition (PCC) in individuals surviving the first year after a SARS-CoV-2 infection. In total, 331 042 individuals were included, of which 852 had persistent PCC. The adjusted risk ratio for developing persistent PCC compared with unvaccinated individuals was 0.81 (95% confidence interval [CI], .59-1.10) for 1 dose, 0.42 (95% CI, .35-.52) for 2 doses, and 0.37 (95% CI, .27-.52) for 3 doses. Reduced risks for vaccinated individuals were also observed when restricting the analyses to pre-Omicron and Omicron, as well as all subgroups including sex, age, and previous infection.