Locoregional infusion of EGFR806-CAR T cells for recurrent or refractory pediatric CNS tumors: Results of the completed BrainChild02 phase 1 clinical trial

Intracranially infused EGFR806-CAR T cells were tolerable at tested doses, with the best response of stable disease. EGFR is a potentially useful target for cellular therapy against pediatric brain tumors, particularly high-grade gliomas.

Authors

Institutions

Publication Details

Journal
Neuro-Oncology
Published
2025-03-05
DOI
https://doi.org/10.1093/neuonc/noaf064
Citations
12
Primary Topic
CAR-T cell therapy research
Type
article
Field-Weighted Citation Impact
12.54
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Locoregional infusion of EGFR806-CAR T cells for recurrent or refractory pediatric CNS tumors: Results of the completed BrainChild02 phase 1 clinical trial

Juliane Gust, Michael C. Jensen, Sowmya Pattabhi, Jason S. Hauptman et al.
12 citations
Neuro-Oncology
CAR-T cell therapy research
12.54
article

Locoregional infusion of EGFR806-CAR T cells for recurrent or refractory pediatric CNS tumors: Results of the completed BrainChild02 phase 1 clinical trial

Juliane Gust, Michael C. Jensen, Sowmya Pattabhi, Jason S. Hauptman, Julie R. Park, Ashley Wilson, Nicholas A. Vitanza, Erin Crotty, Catherine M. Albert, Rebecca J. Ronsley, Francisco A. Perez, Sarah Leary, Stephanie Rawlings-Rhea, Bonnie Cole, Jason N. Wright, Jeffrey G. Ojemann, Jason Wendler, Rebecca Gardner, Navin Pinto, Kristy Seidel, Samuel R. Browd, Amy S. Lee, Christopher Brown, Nadezhda Shtanukhina
article en
12 citations

Abstract

Intracranially infused EGFR806-CAR T cells were tolerable at tested doses, with the best response of stable disease. EGFR is a potentially useful target for cellular therapy against pediatric brain tumors, particularly high-grade gliomas.

Neuro-OncologyVol. 27(8)
Seattle Children's Hospital (US), University of Washington (US), Fred Hutch Cancer Center (US), Seattle Children's Hospital (US), Allen Institute (US), Neurological Surgery (US)
Good health and well-being
Openalex Percentile: Top 1%
CAR-T cell therapy research
12.54
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.