Locoregional infusion of EGFR806-CAR T cells for recurrent or refractory pediatric CNS tumors: Results of the completed BrainChild02 phase 1 clinical trial
Intracranially infused EGFR806-CAR T cells were tolerable at tested doses, with the best response of stable disease. EGFR is a potentially useful target for cellular therapy against pediatric brain tumors, particularly high-grade gliomas.
Authors
- Juliane Gust (ORCID: https://orcid.org/0000-0001-5679-1989)
- Michael C. Jensen (ORCID: https://orcid.org/0000-0001-7477-3063)
- Sowmya Pattabhi (ORCID: https://orcid.org/0000-0003-4403-0925)
- Jason S. Hauptman (ORCID: https://orcid.org/0000-0002-2035-9876)
- Julie R. Park (ORCID: https://orcid.org/0000-0002-6777-9165)
- Ashley Wilson (ORCID: https://orcid.org/0000-0002-4440-001X)
- Nicholas A. Vitanza (ORCID: https://orcid.org/0000-0002-3966-4985)
- Erin Crotty
- Catherine M. Albert (ORCID: https://orcid.org/0000-0001-7610-9932)
- Rebecca J. Ronsley (ORCID: https://orcid.org/0000-0003-3961-3042)
- Francisco A. Perez (ORCID: https://orcid.org/0000-0001-8456-5209)
- Sarah Leary (ORCID: https://orcid.org/0000-0003-0225-6184)
- Stephanie Rawlings-Rhea
- Bonnie Cole (ORCID: https://orcid.org/0000-0002-3471-1949)
- Jason N. Wright (ORCID: https://orcid.org/0000-0002-6676-8253)
- Jeffrey G. Ojemann (ORCID: https://orcid.org/0000-0001-7580-8934)
- Jason Wendler (ORCID: https://orcid.org/0000-0003-4195-8138)
- Rebecca Gardner (ORCID: https://orcid.org/0000-0003-1532-3200)
- Navin Pinto (ORCID: https://orcid.org/0000-0002-8775-6710)
- Kristy Seidel (ORCID: https://orcid.org/0000-0002-8402-0900)
- Samuel R. Browd (ORCID: https://orcid.org/0000-0003-2376-9421)
- Amy S. Lee (ORCID: https://orcid.org/0000-0002-0378-5443)
- Christopher Brown (ORCID: https://orcid.org/0000-0001-7773-0878)
- Nadezhda Shtanukhina
Institutions
- Seattle Children's Hospital (US)
- University of Washington (US)
- Fred Hutch Cancer Center (US)
- Seattle Children's Hospital (US)
- Allen Institute (US)
- Neurological Surgery (US)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-03-05
- DOI
- https://doi.org/10.1093/neuonc/noaf064
- Citations
- 12
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 12.54