Compositional analysis of lymphocytes and their relationship with health outcomes: findings from the health and retirement study
Our findings highlight the value of a systems-based approach and compositional analysis in understanding immunosenescence and its impact on health. The identified subset cells and logratio measures provide meaningful insights into immune aging and warrant further investigation to explore their long-term relationships with health outcomes.
Authors
- Grace A. Noppert (ORCID: https://orcid.org/0000-0002-2040-960X)
- Jennifer B. Dowd (ORCID: https://orcid.org/0000-0003-2006-5656)
- Allison E. Aiello (ORCID: https://orcid.org/0000-0001-7029-2537)
- Rebecca C. Stebbins (ORCID: https://orcid.org/0000-0002-3663-1360)
- Ziman Jiang
- Chihua Li (ORCID: https://orcid.org/0000-0002-0933-8425)
- Kenneth M. Langa (ORCID: https://orcid.org/0000-0002-2798-1836)
- Helen C.S. Meier (ORCID: https://orcid.org/0000-0003-4400-0216)
- Gen Li (ORCID: https://orcid.org/0000-0002-6883-2407)
- Lifei Xu
Institutions
- University of Macau (MO)
- University of Michigan (US)
- Leverhulme Trust (GB)
- University of Oxford (GB)
- Columbia University (US)
Publication Details
- Journal
- Immunity & Ageing
- Published
- 2025-03-12
- DOI
- https://doi.org/10.1186/s12979-025-00505-z
- Citations
- 1
- Primary Topic
- Microscopic Colitis
- Type
- article
- Field-Weighted Citation Impact
- 1.35