Pharmacological inhibition of the Janus Kinases enhances ASCL1 protein stability and transcriptional activity
These compounds may serve as useful tools for further investigating the role played by kinases in regulating neurogenesis and ultimately enable better understanding of how ASCL1 integrates different signalling cues to orchestrate with high precision the differentiation of progenitor cells into neurons.
Authors
- Kirill Shkura (ORCID: https://orcid.org/0000-0002-1722-0910)
- Jeremy Presland (ORCID: https://orcid.org/0000-0003-0288-2441)
- Maya A. Hanspal
- Sébastien Gillotin (ORCID: https://orcid.org/0000-0002-4129-4936)
- Marielza Veiga (ORCID: https://orcid.org/0000-0002-6985-4077)
Institutions
- Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
Publication Details
- Journal
- Molecular Biology Reports
- Published
- 2025-03-12
- DOI
- https://doi.org/10.1007/s11033-025-10367-9
- Primary Topic
- Protein Kinase Regulation and GTPase Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00