Virulence factors, molecular characteristics, and resistance mechanisms of carbapenem-resistant Pseudomonas aeruginosa isolated from pediatric patients in Shanghai, China
This study predominantly identified OprD-mediated carbapenem resistance in pediatric patients. The CRPA isolates were characterized by a variety of STs and a widespread distribution of virulence-associated genes. CC244 demonstrated significantly higher resistance, with potential outbreaks occurring in 2018 and 2019. These findings could aid in managing nosocomial CRPA infections and enhancing clinical practices.
Authors
- Chuanqing Wang (ORCID: https://orcid.org/0000-0002-0158-9094)
- Lu Lu (ORCID: https://orcid.org/0000-0002-6556-8022)
- Guoping Lü (ORCID: https://orcid.org/0000-0002-6815-4554)
- Zihao Bao
- Xiaowen Zhai (ORCID: https://orcid.org/0000-0002-8127-3232)
- Leiyan He
- Lijun Yin
Institutions
- Children's Hospital of Fudan University (CN)
Publication Details
- Journal
- BMC Microbiology
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1186/s12866-025-03856-1
- Citations
- 4
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 2.36
Funders
- National Key Research and Development Program of China