Multifunctional Liposomes with Enhanced Stability for Imaging-Guided Cancer Chemodynamic and Photothermal Therapy

Improvements in tumor therapy require a combination of strategies where targeted treatment is critical. We developed a new versatile nanoplatform, MA@E, that generates high levels of reactive oxygen species (ROS) with effective photothermal conversions in the removal of tumors. Enhanced stability liposomes were employed as carriers to facilitate the uniform distribution and stable storage of encapsulated gold nanorods (AuNRs) and Mn-MIL-100 metal-organic frameworks, with efficient delivery of MA@E to the cytoplasm. In the targeted phagocytosis of tumor cells, MA@E can effectively deplete the reduced glutathione (GSH) with increased hydroxyl radicals that combine with Mn²⁺ released from Mn-MIL-100 to trigger Fenton-like reactions, generating ROS that induces cell apoptosis. Exposure to near-infrared (NIR-II) irradiation results in a AuNRs-induced thermogenic effect that expedites the release of Mn²⁺ and promotes Fenton-like reactions, achieving increased production of ^•OH. In the murine tumor model, MA@E effectively removed the implanted tumor tissue within 2 days without any obvious toxic effects. This response is attributed to a synergism involving the photothermal capability of AuNRs and ROS chemodynamic treatment. The proposed MA@E provides a new approach to utilizing unstable nanomaterials in effective tumor therapy.