Identification of regulator gene and pathway in myocardial ischemia-reperfusion injury: a bioinformatics and biological validation study
This study confirms that S100A9 is a key regulator of I/R progression and may participate in ischemia-reperfusion injury by upregulating RAGE /NFKB-NLRP3 activation. Elevated S100A9 levels may serve as a marker for identifying high-risk MIRI patients, especially those with coronary artery no-reflow (CNR), who might benefit from targeted therapeutic interventions. Furthermore, Peripheral blood S100A9 in AMI represents a new therapeutic target for preventing MIRI.
Authors
- Hongxia Li (ORCID: https://orcid.org/0000-0002-1440-1345)
- Tingbo Jiang (ORCID: https://orcid.org/0000-0001-8109-1634)
- Le Xie (ORCID: https://orcid.org/0000-0002-9810-948X)
- Jiahui Lu (ORCID: https://orcid.org/0000-0001-8449-3495)
- Guanqun Zheng (ORCID: https://orcid.org/0000-0003-4940-0585)
- Xiaodong Sheng (ORCID: https://orcid.org/0000-0002-2897-9068)
- Yanqi Liu (ORCID: https://orcid.org/0000-0003-4540-6410)
- Zhenghong Zhao
Institutions
- Soochow University (CN)
- Changshu No.1 People's Hospital (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Hereditas
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1186/s41065-025-00397-5
- Citations
- 1
- Primary Topic
- S100 Proteins and Annexins
- Type
- article
- Field-Weighted Citation Impact
- 0.81