Gene expression profiles of angiogenesis markers and microRNA-128 from the secretome of umbilical cord mesenchymal stem cells from Macaca fascicularis
Hypoxic preconditioning effectively modulates the expression of key angiogenesis and anti-apoptotic markers in UC-MSCs. The study highlights the importance of optimizing oxygen levels to enhance the therapeutic potential of MSC-derived secretomes for ischemic stroke treatment. Future research should focus on <i>in vivo</i> validation and clinical translation of these findings.
Authors
- Sela Septima Mariya (ORCID: https://orcid.org/0000-0001-5534-1679)
- Fathul Huda (ORCID: https://orcid.org/0000-0002-4818-1862)
- Wireni Ayuningtyas
- Hasta Handayani Idrus (ORCID: https://orcid.org/0000-0002-8563-6395)
- Ahmad Faried (ORCID: https://orcid.org/0000-0003-2967-8125)
- Ratih Rinendyaputri (ORCID: https://orcid.org/0000-0002-7527-4079)
- Sunarno Sunarno (ORCID: https://orcid.org/0000-0002-7012-2738)
- Amarila Malik (ORCID: https://orcid.org/0000-0003-4899-6778)
- Rachmawati Noverina (ORCID: https://orcid.org/0009-0007-6554-1608)
- Putri Reno Intan (ORCID: https://orcid.org/0000-0003-0275-6269)
- Gita Iftitah Renitia
- Yoggi Ramadhani Purwaningtyas (ORCID: https://orcid.org/0009-0001-0759-330X)
- Alvian Dumingan (ORCID: https://orcid.org/0009-0003-3577-1198)
- Hieronimus Adiyoga Nareswara Utama (ORCID: https://orcid.org/0009-0005-1670-5907)
Institutions
- Indonesian Institute of Sciences (ID)
- University of Indonesia (ID)
- Dr. Hasan Sadikin General Hospital (ID)
- PT Bio Farma (Indonesia) (ID)
- Padjadjaran University (ID)
Publication Details
- Journal
- Veterinary World
- Published
- 2025-03-01
- DOI
- https://doi.org/10.14202/vetworld.2025.558-564
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universitas Indonesia