A versatile mouse model to advance human microglia transplantation research in neurodegenerative diseases
The hCSF1<sup>Bdes</sup> mouse is available for both non-profit and for-profit organisations, facilitating the use of the xenotransplantation paradigm for human microglia to study complex human disease.
Authors
- Ivana Geric (ORCID: https://orcid.org/0000-0002-6184-0594)
- Annerieke Sierksma (ORCID: https://orcid.org/0000-0001-9233-972X)
- Bart De Strooper (ORCID: https://orcid.org/0000-0001-5455-5819)
- Lutgarde Serneels (ORCID: https://orcid.org/0000-0002-5463-4231)
- Arya Lekshmi Nair (ORCID: https://orcid.org/0000-0002-8981-4283)
- Emanuela Pasciuto (ORCID: https://orcid.org/0000-0002-5391-9585)
- Anna Martínez‐Muriana (ORCID: https://orcid.org/0000-0002-8645-1317)
- An Snellinx
Institutions
- University of Antwerp (BE)
- UK Dementia Research Institute (GB)
- VIB-UAntwerp Center for Molecular Neurology (BE)
- VIB-KU Leuven Center for Brain & Disease Research (BE)
- University College London (GB)
Publication Details
- Journal
- Molecular Neurodegeneration
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1186/s13024-025-00823-2
- Citations
- 7
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 5.90
Funders
- Alzheimer's Association
- Dementia Research UK
- Queen Elisabeth Medical Foundation
- Fonds Wetenschappelijk Onderzoek
- KU Leuven
- Vlaams Instituut voor Biotechnologie
- Medical Research Council
- HORIZON EUROPE European Research Council