Intrinsic differences in mTOR activity mediates lineage-specific responses to cyclophosphamide in mouse and human granulosa cells
Taken together, our findings reveal that intrinsic variations in mTOR activity in CGC and MGC lineages determine their differential responses to CTX. Targeting this signaling pathway may prove beneficial in mitigating CTX-induced granulosa cell apoptosis and protecting against ovarian injury.
Authors
- Xiaomei Tong (ORCID: https://orcid.org/0000-0002-6982-445X)
- Yibin Pan (ORCID: https://orcid.org/0000-0003-3713-1904)
- Shiqian Xu
- Yerong Ma
- Hanqi Ying
- Yangyang Dai (ORCID: https://orcid.org/0009-0004-7917-9337)
- Songying Zhang (ORCID: https://orcid.org/0000-0001-8615-7196)
- Peidong Han (ORCID: https://orcid.org/0000-0002-6717-4000)
- Rong Yan (ORCID: https://orcid.org/0000-0003-4219-0167)
- Yinli Zhang (ORCID: https://orcid.org/0000-0001-5596-4518)
- Weijie Yang
Institutions
- Zhejiang International Studies University (CN)
- Sir Run Run Shaw Hospital (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Journal of Ovarian Research
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1186/s13048-025-01627-0
- Citations
- 2
- Primary Topic
- Renal and related cancers
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China