Modeling epilepsy by loss-of-function of the CUG-binding protein Elav-like family member 2 in zebrafish with multi-omics analysis
Our study has revealed a promising association between defects in the CELF2 gene and epilepsy using a zebrafish model, suggesting that CLEF2 is a causative gene in epilepsy. These findings not only indicate the potential impact on the biological process influenced by the CELF2 gene defect but also offer hopeful insights into the pathogenesis of epilepsy and potential therapeutic targets.
Authors
- Jing Gan (ORCID: https://orcid.org/0000-0001-5255-6324)
- Huaqin Sun (ORCID: https://orcid.org/0000-0002-4548-4657)
- Xueyi Rao
- Xiaoqian Wang (ORCID: https://orcid.org/0000-0001-6212-1789)
- Jia Zhang (ORCID: https://orcid.org/0000-0001-7869-1284)
- Ziyuan Lin (ORCID: https://orcid.org/0009-0003-4650-495X)
- Yanyan Liu (ORCID: https://orcid.org/0000-0002-3887-0840)
- Rong Luo (ORCID: https://orcid.org/0000-0001-6350-3746)
- Feng Chen (ORCID: https://orcid.org/0009-0007-0545-0720)
Institutions
- Chinese University of Hong Kong (HK)
- Sichuan University (CN)
- West China Second University Hospital of Sichuan University (CN)
Publication Details
- Journal
- Chinese Medical Journal
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1097/cm9.0000000000003398
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00