Branched-Chain Amino Acid Catabolism Promotes Ovarian Cancer Cell Proliferation via Phosphorylation of mTOR
This study uncovers altered amino acid metabolism, specifically increased BCAA catabolism, at the interface of ovarian cancer cells and omental tissue in a coculture model of HGSOC secondary metastasis. Enhanced BCAA catabolism promotes cancer cell proliferation through mTOR signaling, presenting potential therapeutic value. These findings deepen our understanding of HGSOC pathogenesis and the metastatic tumor microenvironment, offering insights for developing new treatment strategies.
Authors
- Hannah J. Lusk (ORCID: https://orcid.org/0000-0001-7379-6909)
- Tova M. Bergsten (ORCID: https://orcid.org/0000-0003-4528-4003)
- Monica A. Haughan (ORCID: https://orcid.org/0009-0006-8581-2332)
- Laura M. Sanchez (ORCID: https://orcid.org/0000-0001-9223-7977)
- Joanna E. Burdette (ORCID: https://orcid.org/0000-0002-7271-6847)
Institutions
- University of California, Santa Cruz (US)
- University of Illinois Chicago (US)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1158/2767-9764.crc-24-0532
- Citations
- 3
- Primary Topic
- Mass Spectrometry Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 2.27
Funders
- National Institutes of Health