Tissue-resident peripheral helper T cells foster hepatocellular carcinoma immune evasion by promoting regulatory B-cell expansion
Our study reveals a novel regulatory mechanism of T PH cell-regulatory B-cell-mediated immunosuppression and provides an important perspective for determining the balance between the differentiation of protumorigenic T PH cells and that of antitumorigenic T FH cells in the HCC microenvironment.
Authors
- Yongwei Hu (ORCID: https://orcid.org/0000-0001-5635-2396)
- Zhixing Liang
- Mengchen Shi
- Linsen Ye (ORCID: https://orcid.org/0000-0001-9632-1949)
- Siqi Li (ORCID: https://orcid.org/0000-0002-4569-1111)
- Kun Li (ORCID: https://orcid.org/0000-0003-3539-8496)
- Yang Yang (ORCID: https://orcid.org/0000-0002-1090-3065)
- Xiaojing Li (ORCID: https://orcid.org/0000-0002-9435-0866)
- Yang Li (ORCID: https://orcid.org/0000-0003-4399-1505)
- Mingshen Zhang
- Haoyuan Yu
Institutions
- Sun Yat-sen University (CN)
- Sixth Affiliated Hospital of Sun Yat-sen University (CN)
- Key Laboratory of Guangdong Province (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- Chinese Medical Journal
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1097/cm9.0000000000003544
- Citations
- 1
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.80