RORγ Bridges Cancer-Driven Lipid Dysmetabolism and Myeloid Immunosuppression

Cancer and a hypercholesterolemic diet independently or collaboratively increase blood cholesterol, which in turn triggers RORγ-dependent expansion of suppressive monocytic MDSCs and M2-like TAMs, thus inhibiting specific antitumor immunity and facilitating disease progression.

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Publication Details

Journal
Cancer Discovery
Published
2025-03-11
DOI
https://doi.org/10.1158/2159-8290.cd-24-0199
Citations
8
Primary Topic
Immune cells in cancer
Type
article
Field-Weighted Citation Impact
6.38

Funders

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article

RORγ Bridges Cancer-Driven Lipid Dysmetabolism and Myeloid Immunosuppression

Marco A. Cassatella, G Ballerini, Gianluigi Condorelli, Chiara Pandolfo et al.
8 citations
Cancer Discovery
Immune cells in cancer
6.38
article

RORγ Bridges Cancer-Driven Lipid Dysmetabolism and Myeloid Immunosuppression

Marco A. Cassatella, G Ballerini, Gianluigi Condorelli, Chiara Pandolfo, Giovanna Finocchiaro, Antonio Sica, Augusto Bleve, Chiara Alì, Daniela Pistillo, Cristina Panico, Simone Serio, Francesca Maria Consonni, Marta Monari, Valentina Garlatti, Marina Sironi, Elettra Barberis, Marcello Manfredi, Martina Incerti
article en
8 citations

Abstract

Cancer and a hypercholesterolemic diet independently or collaboratively increase blood cholesterol, which in turn triggers RORγ-dependent expansion of suppressive monocytic MDSCs and M2-like TAMs, thus inhibiting specific antitumor immunity and facilitating disease progression.

Cancer DiscoveryVol. 15(7)
University of Verona (IT), Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT), Humanitas University (IT), IRCCS Policlinico San Donato (IT), Institute of Genetic and Biomedical Research (IT), Humanitas Mater Domini (IT), National Research Council (IT), IRCCS Humanitas Research Hospital (IT)
Istituto di Ricerche Farmacologiche Mario Negri - IRCCS, Fondazione Cariplo, Associazione Italiana per la Ricerca sul Cancro, Humanitas Research Hospital
Good health and well-being
Openalex Percentile: Top 3%
Immune cells in cancer
6.38
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