RORγ Bridges Cancer-Driven Lipid Dysmetabolism and Myeloid Immunosuppression
Cancer and a hypercholesterolemic diet independently or collaboratively increase blood cholesterol, which in turn triggers RORγ-dependent expansion of suppressive monocytic MDSCs and M2-like TAMs, thus inhibiting specific antitumor immunity and facilitating disease progression.
Authors
- Marco A. Cassatella (ORCID: https://orcid.org/0000-0001-7824-1806)
- G Ballerini
- Gianluigi Condorelli (ORCID: https://orcid.org/0000-0003-0481-6843)
- Chiara Pandolfo (ORCID: https://orcid.org/0000-0001-9029-2534)
- Giovanna Finocchiaro (ORCID: https://orcid.org/0000-0001-6663-1989)
- Antonio Sica (ORCID: https://orcid.org/0000-0002-8342-7442)
- Augusto Bleve (ORCID: https://orcid.org/0000-0003-1585-4722)
- Chiara Alì
- Daniela Pistillo (ORCID: https://orcid.org/0000-0002-7665-3783)
- Cristina Panico (ORCID: https://orcid.org/0000-0002-9198-3676)
- Simone Serio (ORCID: https://orcid.org/0000-0002-7294-2094)
- Francesca Maria Consonni (ORCID: https://orcid.org/0000-0001-5229-0263)
- Marta Monari (ORCID: https://orcid.org/0000-0003-4071-270X)
- Valentina Garlatti (ORCID: https://orcid.org/0000-0001-8428-7392)
- Marina Sironi (ORCID: https://orcid.org/0000-0002-3342-1149)
- Elettra Barberis (ORCID: https://orcid.org/0000-0002-2296-9766)
- Marcello Manfredi (ORCID: https://orcid.org/0000-0003-0632-5618)
- Martina Incerti (ORCID: https://orcid.org/0000-0002-4550-0020)
Institutions
- University of Verona (IT)
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- Humanitas University (IT)
- IRCCS Policlinico San Donato (IT)
- Institute of Genetic and Biomedical Research (IT)
- Humanitas Mater Domini (IT)
- National Research Council (IT)
- IRCCS Humanitas Research Hospital (IT)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1158/2159-8290.cd-24-0199
- Citations
- 8
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 6.38
Funders
- Istituto di Ricerche Farmacologiche Mario Negri - IRCCS
- Fondazione Cariplo
- Associazione Italiana per la Ricerca sul Cancro
- Humanitas Research Hospital