Discovery of the antifungal compound ilicicolin K through genetic activation of the ilicicolin biosynthetic pathway in Trichoderma reesei
By activating a silent BGC in T. reesei, we obtained a high-yielding strain for the production of the antifungal compounds ilicicolin H and the novel ilicicolin K. These two compounds share some structural properties and are thus highly likely to act on the fungal cytochrome bc1 complex, a component of the mitochondrial repository chain. However, they possess different bioactive properties, which might suggest that ilicicolin K may overcome certain limitations of ilicicolin H.
Authors
- Ruth Birner‐Gruenberger (ORCID: https://orcid.org/0000-0003-3950-0312)
- Christian Stanetty (ORCID: https://orcid.org/0000-0001-7692-6932)
- Dominik Schnalzer (ORCID: https://orcid.org/0009-0003-0469-197X)
- Robert L. Mach (ORCID: https://orcid.org/0000-0003-2375-7244)
- Lukas Fourtis
- Matthias Schmal (ORCID: https://orcid.org/0000-0002-3592-4882)
- Thomas Böttcher (ORCID: https://orcid.org/0000-0003-0235-4825)
- Astrid R. Mach‐Aigner (ORCID: https://orcid.org/0000-0002-7575-2317)
- Matthias Schittmayer (ORCID: https://orcid.org/0000-0003-3249-655X)
- Christoph Suster (ORCID: https://orcid.org/0000-0002-9245-9286)
- Christian Zimmermann (ORCID: https://orcid.org/0000-0002-6440-2100)
- Bárbara Hufnagel (ORCID: https://orcid.org/0000-0002-3515-2122)
- Isabella Burger (ORCID: https://orcid.org/0000-0001-6419-1270)
- Kathrin Peikert
Institutions
- University of Vienna (AT)
- TU Wien (AT)
Publication Details
- Journal
- Biotechnology for Biofuels and Bioproducts
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1186/s13068-025-02628-3
- Citations
- 4
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 5.58
Funders
- Austrian Science Fund