From Gene to Intervention: NLRC4 and WIPI1 Regulate Septic Acute Lung Injury Through Autophagy
Our findings revealed that SALI correlated strongly with autophagy, with the downregulation of the two key DEARGs, NLRC4 and WIPI1, attenuating sepsis lung injury via autophagy regulation, highlighting their therapeutic significance in SALI.
Authors
- Zhuohui Liu (ORCID: https://orcid.org/0000-0001-8211-3065)
- Fang� Yang (ORCID: https://orcid.org/0000-0002-1915-8874)
- Hui Chen (ORCID: https://orcid.org/0000-0002-7990-9254)
- Kejian Qian (ORCID: https://orcid.org/0000-0002-0742-0409)
- Fen Liu (ORCID: https://orcid.org/0000-0003-0560-2206)
- Ning Zhao (ORCID: https://orcid.org/0000-0001-6182-7130)
- Xinyi Yang (ORCID: https://orcid.org/0000-0002-6732-7492)
- Wenqiang Tao
- Xiufang Ouyang
- Zhijian Sun
Institutions
- Nanchang University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-03-01
- DOI
- https://doi.org/10.2147/jir.s510691
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00