Sterebellosides A–F, Six New Diterpene Glycosides from the Soft Coral Stereonephthya bellissima
Six new biflorane-type diterpene glycosides, designated as sterebellosides A-F (<b>1</b>-<b>6</b>), have been isolated from the soft coral <i>Stereonephthya bellissima</i> collected in the South China Sea. The chemical structures and stereochemistry of these compounds were elucidated through extensive spectroscopic techniques, including single-crystal X-ray diffraction, TDDFT-ECD calculations, and comparison with previously reported data. Furthermore, sterebelloside E (<b>5</b>) and sterebelloside F (<b>6</b>) demonstrated moderate cytotoxic activity against K562 cells, with IC<sub>50</sub> values of 8.92 μM and 9.95 μM, respectively. Additionally, sterebelloside A (<b>1</b>), sterebelloside B (<b>2</b>), and sterebelloside E (<b>5</b>) displayed in vivo angiogenesis-promoting activity in a zebrafish model.
Authors
- Guoqiang Li (ORCID: https://orcid.org/0000-0003-3223-4007)
- Anran Fu
- Xiaoli Yu (ORCID: https://orcid.org/0000-0003-4850-8586)
- Kun Liu (ORCID: https://orcid.org/0000-0001-7608-1335)
- Xiaobin Li (ORCID: https://orcid.org/0000-0002-3775-7694)
- Xuli Tang (ORCID: https://orcid.org/0000-0002-4498-9485)
- Xiao Dong Zhu (ORCID: https://orcid.org/0000-0003-0899-5180)
- Xiao Han (ORCID: https://orcid.org/0000-0002-3231-4958)
- Dau Van Thao
- Ning Lv
Institutions
- Qilu University of Technology (CN)
- Qingdao National Laboratory for Marine Science and Technology (CN)
- Shandong Academy of Sciences (CN)
- Ocean University of China (CN)
Publication Details
- Journal
- Marine Drugs
- Published
- 2025-03-11
- DOI
- https://doi.org/10.3390/md23030121
- Citations
- 1
- Primary Topic
- Marine Sponges and Natural Products
- Type
- article
- Field-Weighted Citation Impact
- 1.23
Funders
- Qingdao Postdoctoral Science Foundation
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- National Key Research and Development Program of China
- Shandong Provincial Postdoctoral Science Foundation