LncRNA CASC2 mediates SOCS6 mRNA stabilization via U2AF2 recruitment to modulate macrophage polarisation in diabetic retinopathy
CASC2 derived from RPE cells was transported to macrophages, inducing M2 polarisation by stabilising SOCS6 mRNA through the recruitment of U2AF2. This research may provide a foundation for developing novel therapeutic strategies for DR.
Authors
- Peipei Zhong
- Feipeng Wu (ORCID: https://orcid.org/0000-0003-1367-4699)
- Tian Hu (ORCID: https://orcid.org/0000-0002-0888-1223)
- Fan Xiao (ORCID: https://orcid.org/0000-0002-2399-6977)
- Rong Luo (ORCID: https://orcid.org/0000-0002-5694-8824)
Institutions
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Jiangxi Provincial People's Hospital (CN)
Publication Details
- Journal
- Diabetic Medicine
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1111/dme.70014
- Citations
- 1
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.94