Integrated Analysis of <scp>WES</scp> and <scp>scRNA</scp>‐Seq Data Reveals the Genetic Basis of Immune Dysregulation in Unexplained Recurrent Pregnancy Loss
In summary, our study reveals a complex interplay between genetic variants and immune cell dysfunctions in uRPL, emphasizing the role of identified genetic variants in driving pro-inflammatory states. These findings provide a comprehensive view of the molecular mechanisms underlying uRPL, opening paths for novel therapeutic interventions and improved clinical management.
Authors
- Yun Jiao (ORCID: https://orcid.org/0000-0002-9579-8398)
- Shuai Guo (ORCID: https://orcid.org/0009-0004-2988-5663)
- Yanmei Sun (ORCID: https://orcid.org/0000-0002-8938-6696)
- Zhiming Lin (ORCID: https://orcid.org/0000-0002-9341-4303)
- Yujie Jiang (ORCID: https://orcid.org/0000-0003-4031-2781)
- Liang‐Liang Fan (ORCID: https://orcid.org/0000-0001-7431-1838)
- Yali Li (ORCID: https://orcid.org/0000-0002-4863-5713)
- Wei Zhang (ORCID: https://orcid.org/0000-0003-3605-9373)
- Shu Liu (ORCID: https://orcid.org/0000-0001-6907-8787)
- Lei Zhu
- Dong Yi (ORCID: https://orcid.org/0000-0002-7881-216X)
- Yan Zhi (ORCID: https://orcid.org/0000-0003-3945-3915)
Institutions
- Central South University (CN)
- Hebei General Hospital (CN)
- Second Xiangya Hospital of Central South University (CN)
- Wake Forest University (US)
- Southern Medical University (CN)
Publication Details
- Journal
- Journal of Clinical Laboratory Analysis
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/jcla.70011
- Citations
- 2
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- Natural Science Foundation of Hebei Province
- Natural Science Foundation of Hunan Province
- Natural Science Foundation of Inner Mongolia