Iron-Catalyzed Reductive Ring-Rearrangement Reaction of Bridged Benzo[<i>b</i>]oxocin-4-ones with Grignard Reagents to Afford Bridged Benzo[<i>b</i>]oxocin-2-ols
An iron-catalyzed reductive ring-rearrangement reaction of bridged benzo[<i>b</i>]oxocin-4-ones with Grignard reagents to produce bridged benzo[<i>b</i>]oxocin-2-ols is reported. Mechanistic studies indicate that an iron redox catalysis cycle involving oxidative addition to the C-O bond by low-valence iron and β-methoxyl elimination as key steps operates in this reaction.
Authors
- Dunru Zhu (ORCID: https://orcid.org/0000-0003-2124-498X)
- Ruwei Shen (ORCID: https://orcid.org/0000-0002-8834-3256)
- Yishuai Fan
- Run-Jie Peng
- Haoran Yang (ORCID: https://orcid.org/0000-0001-7579-0738)
Institutions
- Nanjing Tech University (CN)
- State Key Laboratory of Materials-Oriented Chemical Engineering
Publication Details
- Journal
- Organic Letters
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1021/acs.orglett.5c00451
- Citations
- 2
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Natural Science Foundation of China
- Nanjing Tech University
- State Key Laboratory of Materials- Oriented Chemical Engineering
- Graduate Research and Innovation Projects of Jiangsu Province