131-Radioiodine Therapy for Graves Disease in a Patient With Down Syndrome and Non-operable Congenital Heart Disease

Thyroid dysfunctions are prevalent in Down syndrome (DS), with hypothyroidism being the most frequent occurrence, whereas hyperthyroidism is rare. DS patients face an increased risk of comorbidities, including gastrointestinal, cardiac, and pulmonary anomalies, as well as developmental delays, endocrine abnormalities, and malignancies, complicating their treatment and management. The published data on pediatric hyperthyroidism in DS from India comprise five case reports with six patients. We report a case of a 13-year-old male child with DS with Graves disease (GD), who had inoperable congenital heart disease (CHD) and was administered iodine-131 radioiodine therapy as a definitive treatment for GD.