Inhibition of 5-hydroxyindoleacetic acid to reduce neutrophil extracellular trap production improves lung condition in chronic obstructive pulmonary disease mice
Inhibiting 5-HIAA reduces NET generation, thereby improving lung conditions in COPD mice, which is associated with the 5-HIAA/AHR pathway.
Authors
- Weijia Zhou
- Qiang Zeng (ORCID: https://orcid.org/0000-0002-2759-422X)
- Wu Li (ORCID: https://orcid.org/0000-0003-3942-0515)
- Wei Xiong (ORCID: https://orcid.org/0000-0003-1635-8173)
- Xiaotian Dai (ORCID: https://orcid.org/0009-0003-1959-1402)
- Cheng Liang
- Lei Xue (ORCID: https://orcid.org/0000-0003-4495-0414)
Institutions
- Army Medical University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Army Medical College (PK)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Annals of Medicine
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1080/07853890.2025.2474734
- Citations
- 3
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 2.39
Funders
- National Key Research and Development Program of China