Adult Hymenolepis nana and its excretory–secretory products elicit mouse immune responses via tuft/IL-13 and FOXM1 signaling pathways
The adult H. nana and its ESP stimulate the immune responses in mice through tuft/interleukin (IL)-13 and FOXM1 signaling pathways and promote the elimination of H. nana from the host through the differentiation of intestinal stem cells into tuft cells, goblet cells, and Paneth cells, as well as the activation of type 2 immune responses. Meanwhile, RCM-1 inhibits the immune responses to H. nana in mice, thus affecting the excretion of H. nana by host.
Authors
- Zhenfen Zhang
- Xiaopeng Cui (ORCID: https://orcid.org/0000-0003-1985-6805)
- Wen‐Lan Wu (ORCID: https://orcid.org/0000-0003-2199-4553)
- Rong Mou (ORCID: https://orcid.org/0000-0002-7340-4482)
- Qingli Luo (ORCID: https://orcid.org/0000-0003-0375-9947)
- Yi Cheng
- Jin-Fu Li (ORCID: https://orcid.org/0000-0003-2659-0793)
- Yu-Si Luo
- Ke Zhang (ORCID: https://orcid.org/0000-0002-6527-3427)
Institutions
- Guiyang Medical University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
- Liupanshui Normal University (CN)
Publication Details
- Journal
- Parasites & Vectors
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1186/s13071-025-06719-w
- Citations
- 3
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 2.39
Funders
- National Natural Science Foundation of China