DYNAMICS OF HEMATOLOGICAL PARAMETERS OF ENDOGENOUS INTOXICATION IN ADULT PATIENTS WITH MEASLES WITH DIFFERENT SEVERITY OF THE DISEASE

Introduction. Measles is a highly contagious infectious disease with upper respiratory tract catarrh, conjunctivitis, stage exanthema and pronounced syndrome of endogenous intoxication.Aim. To determine the degree of endogenous intoxication syndrome in adult patients with measles and make a connection with the severity of the underlying disease.Materials and methods. There were observed 120 adult patients with measles. The diagnosis was confirmed by epidemiological, clinical and laboratory criteria, using the Android-application the integrative indicators of endogenous intoxication and immunoreactivity of the organism were calculated.Results and discussion. Among those studied there were 64 women (53.33%) and 56 (46,66%) men. The average age is 32.16 ± 2.39 years. Residents of Ivano-Frankivsk predominated – 72 (60,0%) patients. There were 29 (24,16%) patients who had received two doses of MMR vaccine, 66 (55,0%) – unvaccinated ones, 25 (20,84%) – vaccination status is unknown. Patients were divided into three groups, two subgroups in each depending on vaccine status. Control group – 40 clinically healthy and anamnestically intact blood donors. Upon admission a hemogram was evaluated based on the results of which integrative hematological indices were calculated. In the early period of the disease the indices of inflammatory activity and intoxication significantly increased,which indicated a violation of immunological reactivity (increased IZLK, IL ESR and decreased ILG) and the formation of an adaptive response of the body (decreased I lymph, ISEL, IA). Comparing the results obtained in vaccinated and unvaccinated patients it was noted that at an early stage of the disease the immunological reactivity in both subgroups is sharply suppressed due to autointoxication and the number of cytokine-producing cells increases, which is more pronounced in vaccinated patients.Conclusions. In recent years, measles has mainly affected young people, urban residents, and those who have not been vaccinated. The used mobile application allows to determine the degree of endogenous intoxication syndrome, is a predictor for severe and complicated course of measles in adult patients and allows to choose the optimal tactics of patient management.