Modeling of lung organoid-based fibrosis for testing the sensitivity of anti-fibrotic drugs
We demonstrate that the LOFs represent an efficient fibrotic model that mimics faithfully the personalized characteristics of native lung tissue.
Authors
- Zihao Liu (ORCID: https://orcid.org/0000-0003-0488-9348)
- Lei Liu (ORCID: https://orcid.org/0000-0002-8717-7364)
- Yulei Wang (ORCID: https://orcid.org/0000-0001-6746-2953)
- Yang Yang (ORCID: https://orcid.org/0000-0002-3875-2473)
- Heping Wang (ORCID: https://orcid.org/0000-0001-9968-8658)
- Wenjian Wang (ORCID: https://orcid.org/0000-0002-1880-3050)
- Yunshan Zhao
- Zhiyi Han
- Jiehua Chen (ORCID: https://orcid.org/0000-0002-1276-3043)
- Yang Huang (ORCID: https://orcid.org/0000-0002-6886-6180)
- L. Xin
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Jingdong (China) (CN)
- Guang’anmen Hospital (CN)
- Shenzhen Children's Hospital (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1186/s13287-025-04251-3
- Citations
- 5
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 7.59
Funders
- High-level Hospital Construction Project of Guangdong Provincial People's Hospital