Integrated functional genomic analysis identifies regulatory variants underlying a major QTL for disease resistance in European sea bass
The SNP variant CHR3:10,077,301, through modulation of IFI27L2 and IFI27L2A genes, is likely the causative mutation underlying resistance to VNN in European sea bass. This is one of the first causative mutations discovered for disease resistance traits in fish and paves the way for marker-assisted selection as well as biotechnological approaches to enhance resistance to VNN in European sea bass and other susceptible species.
Authors
- Ross D. Houston (ORCID: https://orcid.org/0000-0003-1805-0762)
- Giulia Dalla Rovere (ORCID: https://orcid.org/0000-0001-9504-2454)
- Costas S. Tsigenopoulos (ORCID: https://orcid.org/0000-0003-0615-7941)
- Anna Toffan
- Robert Mukiibi (ORCID: https://orcid.org/0000-0001-7586-9593)
- Francesco Pascoli (ORCID: https://orcid.org/0000-0003-2239-3098)
- Luca Peruzza (ORCID: https://orcid.org/0000-0001-5001-8653)
- Rafaella Franch (ORCID: https://orcid.org/0000-0002-1333-0733)
- Serena Ferraresso
- Luca Bargelloni (ORCID: https://orcid.org/0000-0003-4351-2826)
- Massimiliano Babbucci (ORCID: https://orcid.org/0000-0002-4060-4728)
- Sara Faggion (ORCID: https://orcid.org/0000-0001-6031-1431)
- Carolina Peñaloza (ORCID: https://orcid.org/0000-0001-7052-3614)
- Diego Robledo (ORCID: https://orcid.org/0000-0002-9616-5912)
- Daniela Bertotto (ORCID: https://orcid.org/0000-0002-1370-8679)
Institutions
- Roslin Institute (GB)
- University of Padua (IT)
- Universidade de Santiago de Compostela (ES)
- Hellenic Centre for Marine Research (GR)
- Benchmark Animal Health (United Kingdom) (GB)
- Istituto Zooprofilattico Sperimentale delle Venezie (IT)
- University of Edinburgh (GB)
Publication Details
- Journal
- BMC Biology
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1186/s12915-025-02180-4
- Citations
- 8
- Primary Topic
- Aquaculture disease management and microbiota
- Type
- article
- Field-Weighted Citation Impact
- 6.38