Post-reform cannabis use and major depressive episode: A naturalistic investigation

Since cannabis reform, the use of marijuana has surged exponentially. Marijuana use is a widely known risk factor for depression, yet a safe cannabis intake interval has not been investigated in relation to depression. This study presents a comprehensive analysis of the depressive episodes at different levels of cannabis use, as well as socio-demographic correlates of cannabis use, utilizing national survey on drug use and health data collected in 2021. The study involved a nationally representative sample of 47,291 adult residents of the USA. Descriptive and inferential statistical tests were conducted to analyze the prevalence and associations. The study reveals a significant prevalence of marijuana use among the participants, with 51% reporting having used marijuana at some point in their lives. Higher marijuana use was observed with young adults and females. Increased likelihood of lifetime and past-year depression episodes, depression with severe role impairment were observed among cannabis users compared to non-users. However mild cannabis use seems to exhibit certain likelihood of depressive episodes that is next to that of severe consumption. Around 80% of adults considered both heavy and mild marijuana consumption as not posing a great risk for recreational use. These findings highlight the importance of considering the potential risks of marijuana consumption, particularly in relation to depression outcomes. This research contributes valuable insights that can inform targeted interventions and policies aimed at promoting mental health and well-being.