CD4 T cells take center stage during dengue infection
Ansari et al.<sup>1</sup> identified a subset of CD4 T cells (CXCR5<sup>-</sup>PD-1<sup>+</sup>) resembling T follicular helper (Tfh) cells in patients with severe dengue. This subset helps B cell responses via IL-21 and can also differentiate into cytotoxic CD4 T cells.
Authors
- Elsa Gomez‐Escobar (ORCID: https://orcid.org/0000-0003-3071-0954)
- Naglaa H. Shoukry (ORCID: https://orcid.org/0000-0002-8817-8238)
Institutions
- Centre Hospitalier de l’Université de Montréal (CA)
- Université de Montréal (CA)
Publication Details
- Journal
- Cell Reports
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1016/j.celrep.2025.115367
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 0.00