Association Between Alcohol Consumption and the Risk of Incident Chronic Kidney Disease: A Korean Nationwide Study of Community-Dwelling Older Adults

<b>Background/Objectives:</b> This study examined the effects of alcohol consumption on chronic kidney disease (CKD) risk in community-dwelling older adults. <b>Methods:</b> A nationwide retrospective observational study was conducted using NHIS-Senior cohort data (2009-2018). Adults aged ≥ 65 years with an estimated glomerular filtration rate (eGFR) ≥ 60 mL/min/1.73 m<sup>2</sup> were included. Alcohol consumption was classified as non-drinking, mild, moderate, or heavy drinking. CKD onset was defined as eGFR < 60 mL/min/1.73 m<sup>2</sup>. <b>Results:</b> Of the 122,319 subjects, the non-, mild, moderate, and heavy drinking groups comprised 99,091 (81.0%), 14,842 (12.1%), 4257 (3.5%), and 4139 (3.4%), respectively. During follow-up, 19,796 (20.0%), 4636 (31.2%), 1696 (39.8%), and 1695 (41.0%) patients developed CKD in the non-, mild, moderate, and heavy drinking groups, respectively. Univariate Cox regression analyses showed a significantly increased risk of incident CKD in all drinking groups compared with non-drinkers (all <i>p</i> < 0.001). However, hazard ratios (HR) for developing CKD were 0.90 (95% confidence interval [CI] 0.87-0.94, <i>p</i> < 0.001) for mild, 0.89 (95% CI 0.84-0.95, <i>p</i> < 0.001) for moderate, and 0.93 (95% CI 0.88-0.99, <i>p</i> = 0.027) for heavy drinkers. In subgroup analysis, the beneficial effect of alcohol consumption on incident CKD was prominent among moderate drinkers aged 65-74 years and mild drinkers aged ≥ 75 years, in males and mild drinkers aged < 85 years in females. <b>Conclusions:</b> This study shows that alcohol consumption is negatively associated with the risk of incident CKD in older adults, particularly among males.

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Publication Details

Journal
Nutrients
Published
2025-03-11
DOI
https://doi.org/10.3390/nu17060983
Citations
2
Primary Topic
Alcohol Consumption and Health Effects
Type
article
Field-Weighted Citation Impact
2.94

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article

Association Between Alcohol Consumption and the Risk of Incident Chronic Kidney Disease: A Korean Nationwide Study of Community-Dwelling Older Adults

Woo Yeong Park, Chi‐Yeon Lim, Yu Ah Hong, Sungjin Chung et al.
2 citations
Nutrients
Alcohol Consumption and Health Effects
2.94
article

Association Between Alcohol Consumption and the Risk of Incident Chronic Kidney Disease: A Korean Nationwide Study of Community-Dwelling Older Adults

Woo Yeong Park, Chi‐Yeon Lim, Yu Ah Hong, Sungjin Chung, Kyung Don Yoo, Sung Joon Shin, Gang-Jee Ko, Eunjin Bae, Jang‐Hee Cho, In O Sun, Won Min Hwang, Soon Hyo Kwon, Hyunsuk Kim, Jae Won Yang, Sang Heon Song, Byung Chul Yu, Young Youl Hyun, Hui-Seung Lee
article en
2 citations

Abstract

<b>Background/Objectives:</b> This study examined the effects of alcohol consumption on chronic kidney disease (CKD) risk in community-dwelling older adults. <b>Methods:</b> A nationwide retrospective observational study was conducted using NHIS-Senior cohort data (2009-2018). Adults aged ≥ 65 years with an estimated glomerular filtration rate (eGFR) ≥ 60 mL/min/1.73 m<sup>2</sup> were included. Alcohol consumption was classified as non-drinking, mild, moderate, or heavy drinking. CKD onset was defined as eGFR < 60 mL/min/1.73 m<sup>2</sup>. <b>Results:</b> Of the 122,319 subjects, the non-, mild, moderate, and heavy drinking groups comprised 99,091 (81.0%), 14,842 (12.1%), 4257 (3.5%), and 4139 (3.4%), respectively. During follow-up, 19,796 (20.0%), 4636 (31.2%), 1696 (39.8%), and 1695 (41.0%) patients developed CKD in the non-, mild, moderate, and heavy drinking groups, respectively. Univariate Cox regression analyses showed a significantly increased risk of incident CKD in all drinking groups compared with non-drinkers (all <i>p</i> < 0.001). However, hazard ratios (HR) for developing CKD were 0.90 (95% confidence interval [CI] 0.87-0.94, <i>p</i> < 0.001) for mild, 0.89 (95% CI 0.84-0.95, <i>p</i> < 0.001) for moderate, and 0.93 (95% CI 0.88-0.99, <i>p</i> = 0.027) for heavy drinkers. In subgroup analysis, the beneficial effect of alcohol consumption on incident CKD was prominent among moderate drinkers aged 65-74 years and mild drinkers aged ≥ 75 years, in males and mild drinkers aged < 85 years in females. <b>Conclusions:</b> This study shows that alcohol consumption is negatively associated with the risk of incident CKD in older adults, particularly among males.

NutrientsVol. 17(6)
Ulsan College (KR), Harvard University (US), Gyeongsang National University (KR), Yonsei University (KR), Korea University (KR), Dongguk University (KR), Soonchunhyang University (KR), Soonchunhyang University Hospital Seoul (KR), Kyungpook National University Hospital (KR), University of Ulsan (KR), Massachusetts General Hospital (US), Kangbuk Samsung Hospital (KR), Konyang University Hospital (KR), Presbyterian Medical Center (KR), Dongguk University Ilsan Hospital (KR), The Catholic University of Korea Yeouido St. Mary's Hospital (KR), The Catholic University of Korea Daejeon St. Mary's Hospital (KR), Ulsan University Hospital (KR), Hallym University Chuncheon Sacred Heart Hospital (KR), Hallym University Medical Center (KR), Pusan National University (KR), Keimyung University (KR), Bucheon University (KR), Sungkyunkwan University (KR), Catholic University of Korea (KR)
National Research Foundation of Korea, Korean Society of Nephrology
Good health and well-being
Openalex Percentile: Top 11%
Alcohol Consumption and Health Effects
2.94
DOIOpen Access PDFOpenAlex
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