Efficacy and Safety of Intravenous-to-Oral Lascufloxacin Switch Therapy in Community-Onset Pneumonia: A Single-Arm, Open-Label Clinical Trial
Switch therapy using LSFX presented high efficacy and acceptable safety profiles against mild-to-moderate severity of COP. This strategy of using the same drug in both intravenous and oral formulations is quite innovative. LSFX may potentially emerge as one of the preferred options for treating COP.
Authors
- Katsunori Yanagihara (ORCID: https://orcid.org/0000-0003-3677-2486)
- Yuya Ito (ORCID: https://orcid.org/0000-0003-1295-4357)
- Yurika Kawazoe
- Takuto Miyamura (ORCID: https://orcid.org/0000-0002-2685-8000)
- Yoji Futsuki
- Takahiro Takazono (ORCID: https://orcid.org/0000-0002-0696-5386)
- Yoshifumi Imamura (ORCID: https://orcid.org/0000-0003-0034-3698)
- Noriho Sakamoto (ORCID: https://orcid.org/0000-0002-7577-476X)
- Tomo Mihara
- Tsutomu Kobayashi (ORCID: https://orcid.org/0000-0002-5600-5762)
- Shotaro Ide (ORCID: https://orcid.org/0000-0001-7872-8147)
- Satoshi Irifune
- Yusei Tsukamoto
- Shimpei Morimoto (ORCID: https://orcid.org/0000-0002-5340-6851)
- Toru Morikawa (ORCID: https://orcid.org/0000-0001-8014-5282)
- Yosuke Harada (ORCID: https://orcid.org/0000-0001-9827-4963)
- Akira Kondo (ORCID: https://orcid.org/0000-0001-8621-2378)
- Yuichi Inoue (ORCID: https://orcid.org/0000-0001-7414-9017)
- Koichi Izumikawa (ORCID: https://orcid.org/0000-0001-9969-824X)
- Hiroshi Mukae (ORCID: https://orcid.org/0000-0002-1429-5706)
- Yohsuke Nagayoshi (ORCID: https://orcid.org/0000-0002-7139-011X)
- Naoki Iwanaga (ORCID: https://orcid.org/0000-0002-0680-390X)
- Kiyoyasu Fukushima (ORCID: https://orcid.org/0000-0002-1833-7723)
- Toyomitsu Sawai (ORCID: https://orcid.org/0000-0002-1263-1243)
- Hiroaki Senju
- Naoki Hosogaya (ORCID: https://orcid.org/0000-0002-3229-2277)
- Ryosuke Morio
- Masataka Yoshida (ORCID: https://orcid.org/0000-0002-5621-955X)
- Kazuaki Takeda (ORCID: https://orcid.org/0000-0003-1611-4435)
- Hikaru Tanaka (ORCID: https://orcid.org/0000-0001-8171-4459)
- Kohji Hashiguchi
- Yuichi Fukuda
- Naofumi Suyama
- Yoshihisa Kohno
- Eisuke Sasaki
Institutions
- University of Nagasaki (JP)
- Japanese Red Cross Society, Japan (JP)
- Nagasaki Prefectural Shimabara High School (JP)
- Sasebo City General Hospital (JP)
- Nagasaki Ajisai Hospital (JP)
- Nagasaki Medical Center (JP)
- Nishikawa Hospital (JP)
- Japan Community Healthcare Organization (JP)
- Ureshino Medical Center (JP)
- Memorial Hospital (US)
- Nagasaki University Hospital (JP)
- Nagasaki University (JP)
Publication Details
- Journal
- Cureus
- Published
- 2025-03-11
- DOI
- https://doi.org/10.7759/cureus.80404
- Citations
- 1
- Primary Topic
- Pneumonia and Respiratory Infections
- Type
- article
- Field-Weighted Citation Impact
- 1.35