Adjuvant Aspirin Treatment in <i>PIK3CA</i> -Mutated Colon Cancer Patients: The SAKK 41/13 Prospective Randomized Placebo-Controlled Double-Blind Trial
The SAKK 41/13 is the first randomized trial to provide clinical evidence of a protective effect of adjuvant aspirin in patients with resected PIK3CA-mutant colon cancer, with clinically relevant DFS and TTR improvements. Although results were not statistically significant because of premature study closure, adjuvant aspirin warrants individual consideration in patients with resected PIK3CA-mutant colon cancer stage II and III. See related commentary by Drew et al., p. 3107.
Authors
- Wolfram Jochum (ORCID: https://orcid.org/0000-0001-6170-2020)
- Markus Joerger (ORCID: https://orcid.org/0000-0001-6602-6287)
- Ulrich Güller
- Karin Rothgiesser
- Thierry Delaunoit (ORCID: https://orcid.org/0000-0002-4746-2777)
- G. Bodoky (ORCID: https://orcid.org/0000-0002-5659-2020)
- Stefanie Hayoz (ORCID: https://orcid.org/0000-0002-2265-6559)
- Roman Inauen
- Thomas J. Ettrich (ORCID: https://orcid.org/0000-0002-7654-2442)
- Sara De Dosso (ORCID: https://orcid.org/0000-0001-6424-6307)
- Dieter Koeberle (ORCID: https://orcid.org/0000-0002-2742-0115)
- Thibaud Koessler (ORCID: https://orcid.org/0000-0001-9196-9076)
- Sandra Calmonte
- Pierre Michel (ORCID: https://orcid.org/0000-0002-8883-6544)
- Sabina Schacher
- Michael Stahl
- Daniel Horber
Institutions
- University of Bern (CH)
- University of Applied Sciences and Arts of Southern Switzerland (CH)
- Inserm (FR)
- University of St.Gallen (CH)
- Kantonsspital St. Gallen (CH)
- University Hospital of Bern (CH)
- Laboratory for Biomedical Neurosciences (CH)
- Hôpital Charles-Nicolle (FR)
- Ente Ospedaliero Cantonale (CH)
- Ospedale San Giovanni Bellinzona (CH)
- Spital STS (CH)
- Kantonsspital Winterthur (CH)
- University Hospital of Geneva (CH)
- Hôpital de Jolimont (BE)
- Unified Szent István and Szent László Hospital (HU)
- Kantonsspital Münsterlingen (CH)
- Fédération Francophone de Cancérologie Digestive (FR)
- European Organisation for Research and Treatment of Cancer (BE)
- St. Claraspital (CH)
- Kliniken Essen-Mitte (DE)
- Swiss Group For Clinical Cancer Research (CH)
- University Hospital Ulm (DE)
- Université de Rouen Normandie (FR)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-4048
- Citations
- 12
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 12.54