Temporal Dynamics and Clinical Predictors of Brain Metastasis in Breast Cancer: A Two-Decade Cohort Analysis Toward Tailored CNS Screening
Breast cancer remains a significant global health burden for women, yet clear guidelines for routine BMs screening are still lacking. Early detection of BMs has been shown to notably improve long-term survival outcomes. Additionally, post-menopausal status, Hispanic or Arabic ethnicity, and the HER2+ tumor subtype are associated with shorter time to BM development, highlighting these factors as potential indicators for central nervous system screening.
Authors
- Niels Pacheco‐Barrios (ORCID: https://orcid.org/0000-0001-5586-8251)
- Martín A. Merenzon (ORCID: https://orcid.org/0000-0002-2181-9029)
- Fernando Terry (ORCID: https://orcid.org/0000-0002-2177-1643)
- Alejandro Enríquez-Marulanda (ORCID: https://orcid.org/0000-0001-6091-390X)
- Ricardo J. Komotar (ORCID: https://orcid.org/0000-0002-7626-8869)
- Eduardo Orrego-González (ORCID: https://orcid.org/0000-0002-8406-4153)
- Rafael A. Vega (ORCID: https://orcid.org/0000-0002-6444-6082)
Institutions
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- Johns Hopkins University (US)
- University of Miami (US)
- Johns Hopkins Medicine (US)
- Neurological Surgery (US)
Publication Details
- Journal
- Cancers
- Published
- 2025-03-11
- DOI
- https://doi.org/10.3390/cancers17060946
- Primary Topic
- Brain Metastases and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00