Sex Differences in Apolipoprotein E and Alzheimer Disease Pathology Across Ancestries
In this cohort study, the association of the APOE-ε4 risk allele with tau accumulation was higher in women than in men. These findings underscore the importance of considering sex differences in APOE-ε4's association with AD biomarkers and tau pathology mechanisms in AD. Although this study provides robust evidence of complex interplay between sex and APOE-ε4 for European ancestry, further research is needed to fully understand other ancestry differences.
Authors
- Qijun Yang (ORCID: https://orcid.org/0009-0007-3874-1399)
- Timothy J. Hohman (ORCID: https://orcid.org/0000-0002-3377-7014)
- Alberto Lleó (ORCID: https://orcid.org/0000-0002-2568-5478)
- Agustı́n Ruiz (ORCID: https://orcid.org/0000-0003-2633-2495)
- Elaine R. Peskind (ORCID: https://orcid.org/0000-0002-3667-9129)
- Pau Pástor (ORCID: https://orcid.org/0000-0002-7493-8777)
- Xiaoyi Xu (ORCID: https://orcid.org/0000-0001-8432-6291)
- Carlos Cruchaga (ORCID: https://orcid.org/0000-0002-5261-689X)
- José Luís Molinuevo (ORCID: https://orcid.org/0000-0003-0485-6001)
- Yan V. Sun (ORCID: https://orcid.org/0000-0002-2838-1824)
- Catherine Apio (ORCID: https://orcid.org/0000-0003-0240-794X)
- Soomin C. Song (ORCID: https://orcid.org/0000-0002-9581-0991)
- John Budde (ORCID: https://orcid.org/0000-0001-7778-7276)
- John C. Morris (ORCID: https://orcid.org/0000-0001-9820-5618)
- Jennifer M. Kwon (ORCID: https://orcid.org/0000-0002-7720-2490)
- Yuetiva Deming
- Virginia Man-Yee Lee
- Amanda Heslegrave (ORCID: https://orcid.org/0000-0002-7290-6405)
- Kaj Blennow
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0003-3930-4354)
- Gyujin Heo
- Taesung Park (ORCID: https://orcid.org/0000-0002-8294-590X)
- Menghan Liu (ORCID: https://orcid.org/0009-0008-9902-5983)
- Jigyasha Timsina (ORCID: https://orcid.org/0000-0003-4794-9187)
- Marilyn S. Albert
- Ruixin Yan
Institutions
- Cleveland Clinic (US)
- University of Wisconsin–Madison (US)
- Seoul National University (KR)
- Johns Hopkins University (US)
- University of Washington (US)
- Washington University in St. Louis (US)
- Johns Hopkins Medicine (US)
- Hospital de Sant Pau (ES)
- Pasqual Maragall Foundation (ES)
- Hope Center for Neurological Disorders (US)
- Fundació ACE (ES)
- Prevent Alzheimer’s Disease 2020 (US)
- Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol (ES)
- University College London (GB)
- University of Pennsylvania (US)
- University of Gothenburg (SE)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.0562
- Citations
- 19
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 22.12
Funders
- Alzheimer's Association
- National Institutes of Health