Clinical Outcomes of Hypertonic Saline vs Mannitol Treatment Among Children With Traumatic Brain Injury

In this cohort study of children with moderate to severe TBI, the use of HTS was not associated with increased survival or improved functional outcomes compared with mannitol. Future large multicenter randomized clinical trials are required to validate these findings.

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Publication Details

Journal
JAMA Network Open
Published
2025-03-11
DOI
https://doi.org/10.1001/jamanetworkopen.2025.0438
Citations
8
Primary Topic
Traumatic Brain Injury and Neurovascular Disturbances
Type
article
Field-Weighted Citation Impact
11.11
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article

Clinical Outcomes of Hypertonic Saline vs Mannitol Treatment Among Children With Traumatic Brain Injury

Pei Chuen Lee, Jesús Domínguez-Rojas, Hiroshi Kurosawa, Shu‐Ling Chong et al.
8 citations
JAMA Network Open
Traumatic Brain Injury and Neurovascular Disturbances
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article

Clinical Outcomes of Hypertonic Saline vs Mannitol Treatment Among Children With Traumatic Brain Injury

Pei Chuen Lee, Jesús Domínguez-Rojas, Hiroshi Kurosawa, Shu‐Ling Chong, Juan D. Roa, Sebastián González‐Dambrauskas, Mohannad Antar, Deiby Lasso Noguera, María Miñambres Rodríguez, Chin Seng Gan, Jan Hau Lee, Natalia Elizabeth Gómez Arriola, Lijia Fan, Esteban Cerón, Freddy Israel Pantoja Chamorro, J. Pilar Orive, Hongxing Dang, Suyun Qian, Paula Caporal, Nattachai Anantasit, Yasser Kazzaz, Susana Reyes, Juan Camilo Jaramillo-Bustamante, Ivan J. Ardila, Rubén Eduardo Lasso Palomino, Marisol Fonseca Flores, Kai You, Qalab Abbas, Yek Kee Chor, Olive Pei Ee Lee, Soo Lin Chuah, Adriana Yock‐Corrales, Deborah M. Turina, Thelma Elvira Terán Miranda, Natalia Zita Watzlawik, Tao Zhang, Quan Wang, Jian Ji, Chun‐Feng Liu, Yanan Zhu, Jing Wen, Jacqueline Soo May Ong, Gabriela Aparicio, Andrea Leal Barceló, Rujipat Samransamruajkit, Ming Mei Xiu, Cesia J Ortega Ocas
article en
8 citations

Abstract

In this cohort study of children with moderate to severe TBI, the use of HTS was not associated with increased survival or improved functional outcomes compared with mannitol. Future large multicenter randomized clinical trials are required to validate these findings.

JAMA Network OpenVol. 8(3)
Aga Khan University (PK), Johns Hopkins University (US), SingHealth (SG), Chulalongkorn University (TH), Mexican Social Security Institute (MX), National University of Singapore (SG), Universidad de la República de Uruguay (UY), Capital Medical University (CN), Universidad El Bosque (CO), Mahidol University (TH), University of Nariño (CO), Garrahan Hospital (AR), Centro Hospitalario Pereira Rossell (UY), Sarawak General Hospital (MY), King Chulalongkorn Memorial Hospital (TH), University of Malaya (MY), Universidad de Antioquia (CO), BioCruces Health research Institute (ES), SingHealth Duke-NUS Academic Medical Centre (SG), Instituto Nacional de Salud del Niño (PE), KK Women's and Children's Hospital (SG), Hospital Pablo Tobon Uribe (CO), Clínica Santa María (CO), Kobe Children's Hospital (JP), Hospital Nacional de Niños (CR), Hospital de Cruces (ES), Hospital de Niños Superiora Sor María Ludovica (AR), Ramathibodi Hospital (TH), Beijing Children’s Hospital (CN), Hospital Universitario Virgen de la Arrixaca (ES), Children's Hospital of Fudan University (CN), Children's Hospital of Chongqing Medical University (CN), Singapore Clinical Research Institute (SG), Hospital General de Niños Ricardo Gutierrez (AR), National Guard Health Affairs (SA), Icesi University (CO), Chongqing Medical University (CN), National University of Malaysia (MY), China Medical University (CN)
Good health and well-being
Openalex Percentile: Top 2%
Traumatic Brain Injury and Neurovascular Disturbances
11.11
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