Breast tumors from ATM pathogenic variant carriers display a specific genome-wide DNA methylation profile
We showed that breast tumors that arise in women who carry an ATM PV display a specific genome-wide DNA methylation profile. Specifically, the methylation pattern of 27 key gene promoters was predictive of ATM PV status of the women. These genes may also represent new medical prevention and therapeutic targets for these women.
Authors
- Juana Beauvallet (ORCID: https://orcid.org/0009-0001-0538-263X)
- Marie‐Gabrielle Dondon (ORCID: https://orcid.org/0000-0001-6016-8524)
- Anne‐Laure Renault (ORCID: https://orcid.org/0000-0001-6321-3458)
- Eve Cavaciuti (ORCID: https://orcid.org/0000-0001-7086-2149)
- Anne Vincent‐Salomon (ORCID: https://orcid.org/0000-0001-5754-5771)
- Virginie Raynal (ORCID: https://orcid.org/0000-0003-1729-5733)
- Sophia Murat El Houdigui (ORCID: https://orcid.org/0000-0002-0106-1572)
- Séverine Eon‐Marchais (ORCID: https://orcid.org/0000-0001-5021-7775)
- Dorothée Le Gal (ORCID: https://orcid.org/0009-0008-0595-7676)
- Laetitia Fuhrmann (ORCID: https://orcid.org/0000-0003-1755-6307)
- Yue Jiao (ORCID: https://orcid.org/0000-0001-9872-6034)
- Dominique Stoppa‐Lyonnet (ORCID: https://orcid.org/0000-0002-5438-8309)
- Fabienne Lesueur (ORCID: https://orcid.org/0000-0001-7404-4549)
- Nadine Andrieu (ORCID: https://orcid.org/0000-0001-8820-5550)
- Melissa C. Southey (ORCID: https://orcid.org/0000-0002-6313-9005)
- Nicolas M. Viart (ORCID: https://orcid.org/0000-0001-7775-9910)
Institutions
- Inserm (FR)
- The University of Melbourne (AU)
- Cancer Council Victoria (AU)
- Université Paris Cité (FR)
- Université Paris Sciences et Lettres (FR)
- Monash University (AU)
- École Nationale Supérieure des Mines de Paris (FR)
- Institut Curie (FR)
Publication Details
- Journal
- Breast Cancer Research
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1186/s13058-025-01988-w
- Citations
- 1
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Fondation ARC pour la Recherche sur le Cancer
- Institut National Du Cancer
- Université de Recherche Paris Sciences et Lettres
- National Institutes of Health
- Medical Research Council
- National Health and Medical Research Council