Single-cell analysis identifies MKI67+ microglia as drivers of neovascularization in proliferative diabetic retinopathy
The identification of MKI67<sup>+</sup> microglia as a cell type strongly associated with lactate metabolism provides a novel perspective on the mechanisms underlying PDR onset. These findings expand our understanding of the cellular and metabolic dynamics in PDR, emphasizing potential implications for targeted therapeutic interventions.
Authors
- Bibo Ren
- Zhishuo Ou
- Kang Zou (ORCID: https://orcid.org/0000-0002-4959-1951)
- Jian Ye (ORCID: https://orcid.org/0000-0003-3383-1225)
- Xue Li (ORCID: https://orcid.org/0000-0003-4836-7808)
- Fu Cheng (ORCID: https://orcid.org/0000-0002-3052-7650)
Institutions
- Army Medical University (CN)
- Sichuan University (CN)
- Children's Hospital of Chongqing Medical University (CN)
- Southern Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1186/s12967-025-06320-w
- Citations
- 6
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 5.05
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Chongqing