Molecular KRAS ctDNA Predicts Metastases and Survival in Pancreatic Cancer: A Prospective Cohort Study
Detection of mKRAS ctDNA in plasma and peritoneal fluid of patients with localized PDAC is not only feasible but also identifies those at high risk of metastatic progression and worse survival outcomes. It allows for better prognostication and can significantly impact subsequent treatment decisions, particularly in patients where an aggressive surgical approach is being considered.
Authors
- Ryan M. Carr (ORCID: https://orcid.org/0000-0001-5762-367X)
- Patrick P. Starlinger (ORCID: https://orcid.org/0000-0002-4666-5337)
- Robert R. McWilliams (ORCID: https://orcid.org/0000-0002-8199-5040)
- Jennifer L. Leiting (ORCID: https://orcid.org/0000-0002-5784-7937)
- Roberto Alva‐Ruiz (ORCID: https://orcid.org/0000-0002-9796-8098)
- Benjamin R. Kipp (ORCID: https://orcid.org/0000-0001-9477-0118)
- Sean Patrick Cleary (ORCID: https://orcid.org/0000-0002-5274-9983)
- Rory L. Smoot
- Mark Joseph Truty (ORCID: https://orcid.org/0000-0003-3776-527X)
- Danielle M. Carlson (ORCID: https://orcid.org/0000-0003-1823-6380)
- Travis E. Grotz (ORCID: https://orcid.org/0000-0002-7753-097X)
- Jennifer A. Yonkus (ORCID: https://orcid.org/0000-0001-9915-6184)
- Cornelius A. Thiels (ORCID: https://orcid.org/0000-0003-3654-8601)
- Diva R. Salomão (ORCID: https://orcid.org/0000-0001-5066-9667)
- Susanne G. Warner (ORCID: https://orcid.org/0000-0003-4329-7943)
- Isaac T. Lynch (ORCID: https://orcid.org/0000-0003-2163-1226)
- Amro M. Abdelrahman (ORCID: https://orcid.org/0000-0001-9865-0551)
- Michael L. Kendrick (ORCID: https://orcid.org/0009-0005-7960-3254)
Institutions
- University of Toronto (CA)
- Mayo Clinic in Arizona (US)
Publication Details
- Journal
- Annals of Surgical Oncology
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1245/s10434-025-17036-y
- Citations
- 4
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 4.18