Silicone Oil Affects Fibrosis of Human Trabecular Meshwork Cells by Upregulating Ferroptosis Through a ROS/NOX4/Smad3 Axis
These findings highlight the significance of ferroptosis and the ROS/NOX4/Smad3 axis in the mechanism of SiO-induced intraocular pressure elevation. The insights gained from this study identify potential therapeutic targets to mitigate postoperative complications associated with SiO tamponade in ophthalmic surgery.
Authors
- Yisheng Zhong (ORCID: https://orcid.org/0000-0001-5604-6591)
- Shouyue Huang (ORCID: https://orcid.org/0000-0002-0698-0527)
- Huan Yu (ORCID: https://orcid.org/0000-0002-7249-1131)
- Yang Zhang (ORCID: https://orcid.org/0000-0002-2739-1916)
- Jing Wang (ORCID: https://orcid.org/0009-0009-5884-842X)
- Yanzhi Guo (ORCID: https://orcid.org/0000-0003-2087-2757)
- Yumeng Zhang (ORCID: https://orcid.org/0000-0002-6444-292X)
- Huimin Zhong (ORCID: https://orcid.org/0000-0002-1371-6951)
- Ruiqi Han (ORCID: https://orcid.org/0000-0002-7379-8135)
Institutions
- Shanghai Jiao Tong University (CN)
- Ruijin Hospital (CN)
- Shanghai First People's Hospital (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1167/iovs.66.3.25
- Citations
- 2
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 3.04